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Wednesday, 23rd, June 2021
From 11h30 To 12h30
Centre de recherche - Paris - Webinar

Spatiotemporal control over adhesions in synthetic cells using light

Many functions in cells arise directly from the spatial and temporal regulation of cell-matrix and cell-cell interactions. In this talk, I will present strategies of how such spatiotemporal control over adhesions of synthetic and natural cells can be achieved with visible light (blue, green or red light) and functions that arise from these. These light triggered and reversible interactions mimic the dynamics of interactions observed in biology, and allow modulating the interactions as desired without disturbing other processes in the cell. The photoswitchable adhesions allow us to self-assemble and self-sort cells into multicellular functional architectures with high precision, regulate their interactions with synthetic materials, program cell to cell communication and to study the underlying biology. Synthetic minimal cells, which reduce complexity and yet capture key features of natural cells, allow us to quantify and correlate cell behavior with molecular information. Further, complementary approaches pursued with synthetic minimal cells as well as bacterial and mammalian cells allow translating concepts between different systems and integration into hybrid structures.  Overall, our work on one hand provides insight into underlying design principles of life and on the other hand allows addressing questions in cell biology as well as engineer new synthetic cell biology.  

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Seraphine V. Wegner

Institute for Physiological Chemistry and Pathobiochemistry, University of M√ľnster, Germany

Invited by

Mathieu Coppey


Mathieu Coppey

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