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Wednesday, 21st, April 2021
From 11h30 To 12h30
Centre de recherche - Paris - Webinar

Force production and force sensing during clathrin-mediated endocytosis

Clathrin-mediated endocytosis (CME) consists of the formation of a vesicle out of a flat membrane in eukaryotes. When membrane tension and/or turgor pressure are high, actin dynamics is required to produce the forces required to invaginate the membrane and pinch it off into a vesicle. However, how the actin meshwork produces forces at the molecular level has remained elusive, because endocytic structures are intrinsically transient, out of equilibrium, and diffraction limited. In this seminar, I will present results from mathematical modeling and experiments in yeast demonstrating that actin polymerization alone cannot produce sufficient force to invaginate the plasma membrane. I will also present new force production mechanisms by the actin meshwork that are not exclusively based on polymerization, and are relevant to other subcellular processes involving actin and membranes.  

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Julien Berro

Yale University, USA

Invited by

Feng-Ching Tsai