Please note that this seminar is cancelled and postponed until further notice. Thank you for your understanding.
Mammalian immune systems have evolved to fight the widest possible range of threats, from foreign attacks to endogenous dysregulations. For this purpose, lymphocytes diversified into a variety of effectors that play overlapping, non-redundant roles.
On one end of the spectrum, innate lymphoid cells (ILC) mostly reside in tissues, are activated by conserved determinants, and are poised to produce rapid effector responses. On the other end, conventional αβ T cells patrol through the body, are specifically activated by diverse antigens, and generate delayed, but highly specific effector responses adapted to threats. Despite important functional differences between T cells and ILC, the two lineages show fundamental similarities. In particular, T cells and ILC have very similar effector functions controlled by overlapping transcriptional programs.
We study the early steps of T cell and ILC developments, and the transcriptional mechanisms driving these processes. Our studies help understanding how the two lineages diverge from each other during development while keeping access to similar effector programs used at mature stages.
INSERM UMR1232- Nantes (44) - France