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Seminar

Monday, 24th, February 2020
15h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e

Christoph KLEIN - Mechanisms of early metastatic spread and colony formation: insights from the analysis of disseminated cancer cells

Mechanisms of early metastatic spread and colony formation: insights from the analysis of disseminated cancer cells

Melanie Werner-Klein1 & Christoph A. Klein1,2

1Experimental Medicine and Therapy Research, University of Regensburg; 2Fraunhofer Institute of Toxicology and Experimental Medicine, Regensburg, Germany 

Mutation, selection and adaptation are - by convention - thought to occur primarily within the primary tumour. However, we previously noted in breast cancer and melanoma that metastatic dissemination occurs often early and that advanced tumour stages seed relatively fewer cells. This indicates that metastatic founder cells may lodge and evolve considerable periods of time outside the primary tumour. However, it generates a plethora of questions: How do cancer cells survive at distant sites? Which are the founder cells of metastatic colonies and what are their characteristics? Does the environment trigger progression of early-disseminated cancer cells or do late-arriving cancer cells take over incipient metastatic colonies? We try to address these questions by analysing single disseminated cancer cells isolated at various time points of disease. 

The first presentation will focus on mechanisms of early colonization in melanoma and breast cancer. Genomic and transcriptomic data indicate that DCCs spread in a genomically immature state and try to use microenvironmental signals for progression.In the second part, a global perspective will question current concepts of metastatic progression (and the findings of the first presentation) and try to identify experimental roads to address the questions mentioned above.

Event poster

Speaker(s)

Prof. Christoph KLEIN
Chair of Experimental Medicine and Therapy Research and Head of Fraunhofer ITEM Regensburg, project group “personalized tumour therapy”

University of Regensburg, Germany

Dr. Mélanie WERNER KLEIN
Academic Councillor and Group leader “Early systemic cancer”

Institute for Immunology, Regensburg, Germany

Hosted by

Virginie BEL
Resp. Programmes & Partenariats
Centre de Recherche - Direction

Institut Curie

Invited by

Alain Puisieux
Directo of the Research Center
Centre de Recherche - Direction

Institut Curie

Contact

Virginie BEL

Resp. Programmes & Partenariats

Institut Curie

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