A switch in the translation program regulates meiotic maturation in mouse oocytes.
Meiotic maturation is the final step of oogenesis when oocytes undergo two cell divisions without DNA replication to become haploid eggs. During this transition, de-novo accumulation of proteins and degradation of maternal mRNAs support progression through meiosis and render the egg competent for the embryo development. Our projects characterize the switch in the translation landscape that occurs during meiosis at a genome-wide level. Important components of the cell division machinery are regulated in this manner, as Cyclins B1 and B2, two activators of Cdk1, the master regulator of mitosis and meiosis. Overall, our results reveal the bidirectional regulation between the translation program and cell divisions.
Center for Reproductive Sciences, University of California San Francisco
Domain 2 - UMR 3215 / U934 - Genetics and Developmental Biology