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Thursday, October 24th, 2019
Centre de Recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)

The clone dynamics resulting from stem cell renewal in colonic epithelium

Stem cell and clonality : Renewing tissues are maintained by the production of cells by a small populations of founder stem cells. It follows that of the cells undergoing mutation it is the stem cells are the most likely to give rise to clones that become fixed. Moreover, pre-cancerous lesions may still be maintained by stem like cells. For these reasons we are interested in the properties of stem cells and how they are programmed and regulated to allow self-renewal. However, stem cells are not an entirely stable population. Plasticity whereby cells can change their properties or identity in unexpected ways is increasingly recognized both in damaged tissues and in the steady state.

Event poster



CRUK Cambridge Institute and University of Cambridge

Invited by

Allison BARDIN
Domain 2 - UMR 3215 / U934 - Genetics and Developmental Biology

Institut Curie