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Seminar

Monday, October 21st, 2019
10h30
Centre de Recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e

Cellular Biographies: Reconstructing Developmental Trajectories and Lineages

Complex gene expression programs determine the biographies of cells: how a cell divides, becomes specialized and differentiates. I will describe our recent efforts to use single-cell RNA sequencing and CRISPR-Cas9 genome editing to generate new tools to reconstruct differentiation trajectories and lineage trees at very large scales. Using mesoderm and brain development as examples, I will discuss the opportunities and challenges for these technologies to reveal the developmental biology of cells (also see McKenna et al. Science 2016; Farrell et al. Science 2018; Raj et al. Nature Biotechnology 2018).

Speaker(s)

Prof. Alex Schier
Leo Erikson Life Sciences Professor at Harvard University/Director of the Biozentrum

Harvard University/Biozentrum Basel

Hosted by

Shauna Katz
Labex DEEP

Institut Curie

Invited by

Silvia Fre
Domain 2 - UMR 3215 / U934 - Genetics and Developmental Biology

Institut Curie

Filippo Del Bene
Domain 2 - UMR 3215 / U934 - Genetics and Developmental Biology

Institut Curie

Contact

Shauna Katz

Institut Curie

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