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Monday, June 24th, 2019
Centre de Recherche - Paris - Amphith√©√Ętre Marie Curie

A T cell-centric view of ILC differentiation

Innate lymphoid cells (ILCs) and natural killer (NK) cells have gained considerable interest due to their important roles in immune defense and tissue homeostasis. Our current understanding of how these develop has been greatly facilitated by our extensive knowledge of T cell biology. Established models of T cell differentiation have provided the conceptual basis for a classification of ILCs and NK cells as innate homologues of adaptive T helper cells and cytotoxic T cells, respectively. Furthermore, NK cell and ILC activation finds parallels with known regulatory mechanisms within the T cell system. Here, I will examine the process of NK cell and ILC development from a ‘T cell perspective’ in an attempt to extend the analogy between adaptive T cells and their innate ILC and NK cell counterparts.


James Di Santo

Innate Immunity Unit, Inserm U1223, Institut Pasteur, Paris, France

Invited by

Sebastian Amigorena
Domain 3 - U932 - Immunity and Cancer

Institut Curie


Elodie Mieville

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I received a combined M.D./Ph.D. in 1989/1991 from Cornell University Medical College and the Memorial Sloan–Kettering Cancer Center, and completed post-doctoral training with Alain Fischer in Paris, where I characterized several genes responsible for primary human immunodeficiency syndromes. In 1994, I became a permanent staff scientist with the Institut National de la Santé et de la Recherche Médicale (Inserm) and spent a year as an EMBO visiting scientist at the University of Genetics in Cologne Germany with Pr. Klaus Rajewsky. In 1999, I moved my laboratory to the Immunology Department of the Institut Pasteur, where I directed the Immunology Department from 2002-2006. Current research themes in the Innate Immunity Unit include the study of natural killer and innate lymphoid cells and ‘humanized’ mouse models to study human disease.


Selection of 5 publications

1: Xu W, Cherrier DE, Chea S, Vosshenrich C, Serafini N, Petit M, Liu P, Golub R,
Di Santo JP. An Id2(RFP)-Reporter Mouse Redefines Innate Lymphoid Cell Precursor
Potentials. Immunity. 2019 Apr 16;50(4):1054-1068.e3. doi:
10.1016/j.immuni.2019.02.022. Epub 2019 Mar 26. PubMed PMID: 30926235; PubMed
Central PMCID: PMC6477155.

2: Cherrier DE, Serafini N, Di Santo JP. Innate Lymphoid Cell Development: A T
Cell Perspective. Immunity. 2018 Jun 19;48(6):1091-1103. doi:
10.1016/j.immuni.2018.05.010. Review. PubMed PMID: 29924975.

3: Lim AI, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N,
Puel A, Bustamante J, Surace L, Masse-Ranson G, David E, Strick-Marchand H, Le
Bourhis L, Cocchi R, Topazio D, Graziano P, Muscarella LA, Rogge L, Norel X,
Sallenave JM, Allez M, Graf T, Hendriks RW, Casanova JL, Amit I, Yssel H, Di
Santo JP. Systemic Human ILC Precursors Provide a Substrate for Tissue ILC
Differentiation. Cell. 2017 Mar 9;168(6):1086-1100.e10. doi:
10.1016/j.cell.2017.02.021. PubMed PMID: 28283063.

4: Xu W, Domingues RG, Fonseca-Pereira D, Ferreira M, Ribeiro H, Lopez-Lastra S,
Motomura Y, Moreira-Santos L, Bihl F, Braud V, Kee B, Brady H, Coles MC,
Vosshenrich C, Kubo M, Di Santo JP, Veiga-Fernandes H. NFIL3 orchestrates the
emergence of common helper innate lymphoid cell precursors. Cell Rep. 2015 Mar
31;10(12):2043-54. doi: 10.1016/j.celrep.2015.02.057. Epub 2015 Mar 19. PubMed
PMID: 25801035.

5: Satoh-Takayama N, Serafini N, Verrier T, Rekiki A, Renauld JC, Frankel G, Di
Santo JP. The chemokine receptor CXCR6 controls the functional topography of
interleukin-22 producing intestinal innate lymphoid cells. Immunity. 2014 Nov
20;41(5):776-88. doi: 10.1016/j.immuni.2014.10.007. Epub 2014 Nov 6. PubMed PMID: