Paracrine Communication between Stem-like Cells and Endothelial Cells in Glioblastoma
Glioblastoma (GBM) are the most common and aggressive primary brain tumors and among the most lethal forms of adult cancer. Current therapeutic approaches consist of maximal surgical resection followed by chemo- and radiotherapy. However, this regimen is largely ineffective and GBM almost invariably recur, resulting in a median survival of around 15 months. There is therefore a pressing medical need to boost basic and translational research to fight this devastating disease.
GBM stem-like cells (GSC) constitute a reservoir of malignant cells able to initiate, maintain, and repopulate the tumor mass. They reside in the vicinity of endothelial cells, which fuel and maintain their properties, suggesting that GSC expansion relies on bidirectional communication. Yet, the specific role of endothelial cells is underestimated, while the signaling pathways required for GSC expansion remain elusive. We are therefore exploring the mode of communication between GSC and endothelial cells (such as extracellular vesicles), how they regulate each other phenotype, and how standard treatments impacts their reciprocal signaling.
Research Director CNRS
UMR_S 1232 Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Domain 1 - UMR 3347 / U1021 - Normal and pathological signaling