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Seminar

Wednesday, March 27th, 2019
From 11h30 To 12h30
Centre de Recherche - Paris - Amphith√©√Ętre Marie Curie

Mechanobiology of Biological Membranes: from Mechanotransduc​tion to Artificial Cells

 Biological membranes are involved in a large number of cellular processes including cell migration, membrane trafficking, and cell signaling. Significant amount of work have elucidated the molecular machineries that regulate dynamic membrane-based processes. In parallel, there are growing interests in recent years in trying to understand how mechanical state of the cells are utilized as a regulatory input to control cellular processes. My lab is broadly interested in studying the mechanochemical responses of biological systems. In this talk, I will present two directions related to this theme. On the cellular level, we have investigated the effect of tension on clathrin-mediat​ed endocytosis, and the role the endocytic protein epsin plays in clathrin-coated pit formation under different tension environments. I will also discuss the mechanotransduc​tion pathways of epithelial cancer cells under mechanical compression. In the area of bottom-up synthetic biology, we are building cell-like systems that can sense mechanical input and transduce a biochemical response. To this end, we are attempting to build artificial platelets that mimic the functionalities of natural platelets. I will discuss several modular platforms that we have developed that together will integrate into functional artificial cells.

Speaker(s)

Allen Liu

Mechanical Engineering, University of Michigan

Invited by

Patricia Bassereau
Christophe Lamaze