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Wednesday, March 27th, 2019
From 11h30 To 12h30
Centre de Recherche - Paris - Amphith√©√Ętre Marie Curie

Mechanobiology of Biological Membranes: from Mechanotransduc​tion to Artificial Cells

 Biological membranes are involved in a large number of cellular processes including cell migration, membrane trafficking, and cell signaling. Significant amount of work have elucidated the molecular machineries that regulate dynamic membrane-based processes. In parallel, there are growing interests in recent years in trying to understand how mechanical state of the cells are utilized as a regulatory input to control cellular processes. My lab is broadly interested in studying the mechanochemical responses of biological systems. In this talk, I will present two directions related to this theme. On the cellular level, we have investigated the effect of tension on clathrin-mediat​ed endocytosis, and the role the endocytic protein epsin plays in clathrin-coated pit formation under different tension environments. I will also discuss the mechanotransduc​tion pathways of epithelial cancer cells under mechanical compression. In the area of bottom-up synthetic biology, we are building cell-like systems that can sense mechanical input and transduce a biochemical response. To this end, we are attempting to build artificial platelets that mimic the functionalities of natural platelets. I will discuss several modular platforms that we have developed that together will integrate into functional artificial cells.


Allen Liu

Mechanical Engineering, University of Michigan

Invited by

Patricia Bassereau
Christophe Lamaze