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Seminar

Wednesday, May 15th, 2019
11h30
Centre de Recherche - Orsay - Amphithéâtre du Bâtiment 111

The Quest to Unravel the Complex Biology of Glioblastoma: from Genomics and Beyond

Glioblastomas (GBMs) are the most frequent and aggressive primary tumors in the
central nervous system owing to their fast clinical course and uniform lethality In the
past decade, there has been a big step forward in the identification of the genomic
and epigenomic alterations found in GBM patients. However, the translation of the
(epi)genomic findings into our understanding of the complex biology that drives GBM
pathogenesis has been lagging behind. GBM is a highly heterogeneous disease,
both at the inter- and intra-tumoral level. Furthermore, GBM tumor cells, especially
glioma stem-like initiating cells, are extremely plastic and have an intrinsic ability to
transition from one subtype to another. The best characterized of these transitions is
the mesenchymal transition, which is associated to resistance to radiotherapy and
anti-angiogenics. In this talk, I'll discuss some of our efforts to further understand the
biology behind the different molecular subtypes of GBM and the transitions between
them in an effort to find some actionable pathways for the treatment of these tumors.

Speaker(s)

Núria de la Iglesia, PhD

Glioma and Neural Stem Cell Group August Pi i Sunyer Biomedical Research Institute (IDIBAPS)

Invited by

Giorgio Seano
Domain 1 - UMR 3347 / U1021 - Normal and pathological signaling

Institut Curie

Contact

Giorgio Seano

Institut Curie

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