Extracellular vesicles in Obstetrics and Gynaecology: Focus on pregnancy complications and ovarian cancer
I am a group leader and senior Lions Medical Research Foundation (LMRF) Fellow working at the University of Queensland Centre for Clinical Research (UQCCR). I am recognized as a national and international researcher working in the field of extracellular vesicles focusing on the reproductive biology (specifically in pregnancy and its complications) and I have been consistently invited as a speaker to both National and International meetings (e.g. Society of Reproductive investigation, American Diabetes Association, and International Society for Prenatal Diagnosis). I have 88 publications (42 as first or last author), which 68 are in the extracellular vesicles field. Within UQCCR, I have established and lead the EXOSOME BIOLOGY LABORATORY that conforms the ISO standards (ISO17025 and 13485), in which human exosomes can be isolated, characterised and their role elucidated to evaluate their clinical utility as biomarkers of disease and therapeutic interventions. Over the last 5 years, I have obtained exciting data suggesting that exosomes (i.e. membrane-bound nanovesicles) play a role throughout gestation, including, mediating a placental response to hyperglycaemia and insulin sensitivity. In addition, Ovarian cancer is the most lethal gynaecological cancer worldwide with the lack of early detection an important contributor to poor patient outcomes, thus, my group have been working on the potential role of exosomes in the diagnosis, drug delivery and real-time monitoring of ovarian cancer.
PhD, DMedSc, MSc
Head of the Exosomes Biology Laboratory, University of Queensland Centre for Clinical Research, Brisbane - Australia
Domain 3 - U932 - Immunity and Cancer