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Seminar

Monday, February 18th, 2019
14h
Centre de Recherche - Paris - Amphithéâtre Antoine Lacassagne

Virus defense at the brain border

5 recent publications:

Chhatbar C, Detje CN, Grabski E, Borst K, Spanier J, Ghita L, Elliott DA, Jordão MJC, Mueller N, Sutton J, Prajeeth CK, Gudi V, Klein MA, Prinz M, Bradke F, Stangel M, Kalinke U. Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis. Cell Rep. 2018 Oct 2;25(1):118-129.e4

Koestner W, Spanier J, Klause T, Tegtmeyer PK, Becker J, Herder V, Borst K, Todt D, Lienenklaus S, Gerhauser I, Detje CN, Geffers R, Langereis MA, Vondran FWR, Yuan Q, van Kuppeveld FJM, Ott M, Staeheli P, Steinmann E, Baumgärtner W, Wacker F, Kalinke U. Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice. PLoS Pathog. 2018 Aug 3;14(8):e1007235.

Borst K, Frenz T, Spanier J, Tegtmeyer PK, Chhatbar C, Skerra J, Ghita L, Namineni S, Lienenklaus S, Köster M, Heikenwaelder M, Sutter G, Kalinke U. Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis. J Hepatol. 2017 Dec 21.

Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U. Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Rep. 2017 Jun 13;19(11):2345-2356.

Frenz T, Grabski E, Buschjäger D, Vaas LA, Burgdorf N, Schmidt RE, Witte T, Kalinke U. CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. J Allergy Clin Immunol. 2016 Aug;138(2):586-589.e10.

Speaker(s)

Ulrich Kalinke

TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Hanover, Germany

Invited by

Nicolas Manel
Domain 3 - U932 - Immunity and Cancer

Institut Curie

Contact

Nicolas Manel

Institut Curie