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Seminar

Friday, January 18th, 2019
16h40
Centre de Recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e

Late stage (radio)fluorination. Lessons to be learned from the fluorinase enzyme

The impact of fluorine chemistry in the life sciences is enormous.  As many as 30−40% of agrochemicals and 20% of pharmaceuticals on the market are estimated to contain fluorine. 19F- and 18F-labelled compounds are also finding increasing applications in imaging such as Magnetic Resonance Imaging [MRI] or Positron Emission Tomography [PET]. As a result, there is an increasing demand for facile methods allowing for the fluorination using 19F and the radioisotope 18F of a large variety of structurally complex and functionalised small molecules as well as biologics. This lecture will discuss our recent contributions to the field of late stage fluorination with an emphasis on the challenges associated with the use of alkali metal fluoride, and how these can be overcome. The fluorinase enzyme will serve as a starting point for discussion.

Event poster

Speaker(s)

Véronique Gouverneur
Professor of Chemistry

University of Oxford, UK

Hosted by

Marco Lucchino
PhD Student
Domain 4 - UMR 3666 / U1143 - Chemical Biology of Membranes and Therapeutic Delivery

Institut Curie

Invited by

Ludger Johannes
Directeur Unité
Domain 4 - UMR 3666 / U1143 - Chemical Biology of Membranes and Therapeutic Delivery

Institut Curie

Raphaël Rodriguez
Team Leader
Domain 4 - UMR 3666 / U1143 - Chemical Biology of Membranes and Therapeutic Delivery

Institut Curie

Contact

Marco Lucchino

PhD Student

Institut Curie

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