T cell responses in multiple sclerosis and its animal model
Multiple sclerosis (MS) is thought to be a T cell driven inflammatory disease of the central nervous system (CNS) leading to progressive neurological deficits. CD4+ and CD8+ T cell subsets infiltrate the CNS and have been linked to MS pathogenesis However, the contribution of invariant T cells to MS pathogenesis, such as mucosal associated invariant T (MAIT) cells is not well understood. Firstly, I will report on novel evidence for the role of MAIT cells in setting up CNS inflammation. Moreover, disease activity of MS and its animal model is temporarily suppressed by pregnancy. The mechanism how T cell responses in MS are modulated by pregnancy is largely unknown. Secondly, I will present findings indicating that pregnancy supports the expansion of Treg clonotypes that are specifically equipped to suppress encephalitogenic T cell responses.
Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany
Domain 3 - U932 - Immunity and Cancer