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Séminaire

Jeudi 6 Décembre 2018
De 11h à 12h30
Centre de Recherche - Paris - Amphithéâtre Hélène Martel-Massignac

Genome-scale modeling of cancer metabolism: from in-silico simulations to in-vivo experiments and back

Metabolic reprogramming is one of the earliest described hallmarks of cancer cells transformation. For this reason the study of cancer metabolism is key to discover cancer specific metabolic vulnerabilities that could be therapeutically exploited. With the increasing availability of large collections of omic data, such as the Cancer Cell Line Encyclopaedia or the Cancer Genome Atlas, genome-scale models have become a powerful tool to integrate heterogeneous source of data, as well as to run computer simulations used to generate experimentally testable hypotheses. In this seminar I will introduce the constraint-based modeling framework and its application to the study of cancer. Finally, I will show how wrong predictions can be exploited to refine our current model of cell metabolism.

Orateur(s)

Dr Miguel PONCE DE LEON
Researcher - Computational Biology Life Science Group

BSC Barcelona Supercomputing Center

Organisateur(s)

Dr Emmanuel BARILLOT
Directeur U900
Domain 3 - U900 - CBIO - Bioinformatics, Biostatistics Epidemiology and Computational Systems

Institut Curie

Invité(e)(s) par

Dr Arnau MONTAGUD
Researcher SysBio group - E. Barillot