Iron metabolism and its role in breast cancer
Dysregulation of iron metabolism in cancer is well-documented, and it has been suggested that there is an interdependence between excess iron and inreased cancer incidence and progression. This talk will discuss linkages between iron metabolism and breast cancer by way of an intracellular mathematical model that connects iron homeostasis, iron utilization, oxidative stress response, and relevant oncogenic pathways. The talk will also discuss the role played by the tumor microenvironment and how it can be captured through multiscale modeling.
Professor Dept. of Cell Biology, UConn School of Medecine, Jackson Lab. for Genomic Med. - Director Center for Quantitative Med.
Center for Quantitative Medicine - University of Connecticut School of Medicine and Jackson Laboratory for Genomic Medicine
Directeur de l'U900
Domain 3 - U900 - CBIO - Bioinformatics, Biostatistics Epidemiology and Computational Systems