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Mercredi 21 Novembre 2018
De 10h30 à 11h30
Centre de Recherche - Paris - Amphithéâtre Antoine Lacassagne

From transient compartmentalization to cell population dynamics

In the fifties, Oparin imagined liquidlike compartments called 

coacervates, which could have played a central role in the origin of life [1].

Although the experimental verification of this idea remained scarce for many

years, the idea resurfaced recently in various systems of biological interest

 in which liquid non-membrane compartments were found. An important aspect

not tested in the Oparin scenario is the role of the transient nature of 

compartmentalization. Here, we discuss a general class of multilevel selection

with transient compartmentalization [2], and its robustness against noise

and mutations. In a second part, time permitting, I will present a recent 

theoretical study of cell growth and cell division in a population of growing cells [3].


[1] Origin of life, A. I. Oparin (1952).

[2] Selection dynamics in transient compartmentalization,

A. Blokhuis, D. Lacoste, P. Nghe, L. Peliti, Phys. Rev. Lett. 120, 158101 (2018).

[3] Linking lineage and population observables in cell growth, R. Garcia-Garcia, 

A. Genthon and D. Lacoste (under review)


David Lacoste

Laboratoire PCT, ESPCI

Invité(e)(s) par

Jacques Prost