> Back to seminars list

Seminar

Wednesday, October 31st, 2018
11h30
Centre de Recherche - Orsay - Amphithéâtre du Bâtiment 111

Imprinted loci as a model for studying epigenetic regulation of alternative polyadenylation

The transcriptome of a cell is tightly regulated by epigenetic mechanisms including DNA methylation and histone modifications. We previously found that epigenetic mechanisms can influence the utilization of alternative polyadenylation sites and induce intron retention. Others have shown that epigenetic factors influence alternative splicing. We have exploited an imprinted locus to examine the contribution of epigenetic factors to RNA processing in detail. While CpG islands (CGIs) are generally associated with the transcription start sites of genes, we have examined intragenic CpG islands (iCGIs) located in gene bodies because a major role of iCGIs is linked to tissue-specific gene expression where tight control over transcription during development is crucial. Using a broader approach and examining the entire mammalian genome in two species, we found that DNA methylation and histone modifications work in a tissue-specific context to influence poly(A) site choice and generate transcriptome diversity.

Event poster

Speaker(s)

Dr. Oakey Rebecca

Professor of Epigenetics | Dean for Doctoral Studies | King's College London, UK

Invited by

Martin Dutertre
Domain 1 - UMR 3348 - Genotoxic Stress and Cancer

Institut Curie

Deborah Bourchis
Domain 2 - UMR 3215 / U934 - Genetics and Developmental Biology

Institut Curie

Contact

Martin Dutertre

Institut Curie

Send an e-mail

Deborah Bourchis

Institut Curie

Send an e-mail