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Friday, October 19th, 2018
Centre de Recherche - Paris - Amphith√©√Ętre Marie Curie

Simplicity within complexity of type 1 interferon signaling as evaluated by CRISPR/Cas9 generated knockouts

Recent articles: 


Promiscuous Protein Binding as a Function of Protein Stability.

Cohen-Khait R, Dym O, Hamer-Rogotner S, Schreiber G.

Structure. 2017 Dec 5;25(12):1867-1874.e3. doi: 10.1016/j.str.2017.11.002.




Dynamic Modulation of Binding Affinity as a Mechanism for Regulating Interferon Signaling.

Li H, Sharma N, General IJ, Schreiber G, Bahar I.

J Mol Biol. 2017 Aug 4;429(16):2571-2589. doi: 10.1016/j.jmb.2017.06.011. Epub 2017 Jun 23.




Type I interferons induce apoptosis by balancing cFLIP and caspase-8 independent of death ligands.

Apelbaum A, Yarden G, Warszawski S, Harari D, Schreiber G.

Mol Cell Biol. 2013 Feb;33(4):800-14. doi: 10.1128/MCB.01430-12. Epub 2012 Dec 10.




A robust type I interferon gene signature from blood RNA defines quantitative but not qualitative differences between three major IFNβ drugs in the treatment of multiple sclerosis.

Harari D, Orr I, Rotkopf R, Baranzini SE, Schreiber G.

Hum Mol Genet. 2015 Jun 1;24(11):3192-205. doi: 10.1093/hmg/ddv071. Epub 2015 Feb 26.




Structural linkage between ligand discrimination and receptor activation by type I interferons.

Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC.

Cell. 2011 Aug 19;146(4):621-32. doi: 10.1016/j.cell.2011.06.048.




Prof. Gideon Schreiber

Dept. Biomolecular Sciences Director of I-CORE on Integrated Structural Cellular Biology Weizmann Institute of Science Rehovot, 76100 Israel

Hosted by

Dr. Christophe Lamaze

Invited by

Dr. Christophe Lamaze
Domain 4 - UMR 3666 / U1143 - Chemical Biology of Membranes and Therapeutic Delivery

Institut Curie

Dr. Philippe Benaroch
Domain 3 - U932 - Immunity and Cancer

Institut Curie


M. Yannick Bono