Molecular Architecture and Physiological Function of Caveolae
Caveolae are an abundant feature of the plasma membrane of many mammalian cells, but the cell biology of these structures remains incompletely understood. My seminar will present recent data on the protein complexes that generate caveolae, including a large complex to determine the size and membrane shape of caveolae and a smaller complex that plays a role in the higher-order assembly of clusters of caveolae. I will also present a polemical view of the function of caveolae, arguing that much of the published experimental data can be explained by a simple model in which caveolae act as buffers for mechanical tension within the membrane.
MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH
Domain 4 - UMR 3666 / U1143 - Chemical Biology of Membranes and Therapeutic Delivery