> Back to seminars list

Seminar

Friday, October 12th, 2018
From 11h30 To 13h
Centre de Recherche - Paris - Amphith√©√Ętre Antoine Lacassagne

Multiple ways of altering the gene regulatory program in cancers: focus on transcription factors, DNA methylation, and microRNAs

While most cancer studies focused on patient variations lying in protein-coding regions, the noncoding ~98% of the genome, containing cis-regulatory regions that control when and where genes are expressed, is largely unexplored. Transcription factors are key proteins binding to cis-regulatory regions to modulate the rate of gene transcription. Delineating the specific positions at which a TF binds DNA is of high importance in deciphering gene regulation. As cancer is a disease of disrupted cellular regulation, it is critical to analyze these regions to highlight patient somatic mutations and epigenetic modifications altering the gene regulatory program of the cells. In this talk, I will present our recent works on improving our capacity to predict direct TF-DNA interactions and highlighting somatic mutations and DNA methylation alteration that shift the regulation of protein coding and microRNA genes expression in cancer patients.

Speaker(s)

Dr. Anthony MATHELIER
Group Leader - Computational Biology & Gene Regulation Group Centre for Molecular Medicine Norway (NCMM) Adjunct Researcher - Dept. of Cancer Genetics, http://mathelierlab.com

Oslo University Hospital

Hosted by

Dr. Inna KUPERSTEIN
Computational Systems Biology of Cancer Team

Institut Curie

Invited by

Dr. Emmanuel BARILLOT
Directeur de l'U900

Institut Curie

Contact

Mrs. Caroline BELLIERE DAHAN

Admin Officer U900

Send an e-mail