Multiple ways of altering the gene regulatory program in cancers: focus on transcription factors, DNA methylation, and microRNAs
While most cancer studies focused on patient variations lying in protein-coding regions, the noncoding ~98% of the genome, containing cis-regulatory regions that control when and where genes are expressed, is largely unexplored. Transcription factors are key proteins binding to cis-regulatory regions to modulate the rate of gene transcription. Delineating the specific positions at which a TF binds DNA is of high importance in deciphering gene regulation. As cancer is a disease of disrupted cellular regulation, it is critical to analyze these regions to highlight patient somatic mutations and epigenetic modifications altering the gene regulatory program of the cells. In this talk, I will present our recent works on improving our capacity to predict direct TF-DNA interactions and highlighting somatic mutations and DNA methylation alteration that shift the regulation of protein coding and microRNA genes expression in cancer patients.
Group Leader - Computational Biology & Gene Regulation Group Centre for Molecular Medicine Norway (NCMM) Adjunct Researcher - Dept. of Cancer Genetics, http://mathelierlab.com
Oslo University Hospital
Computational Systems Biology of Cancer Team
Directeur de l'U900