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Séminaire

Mercredi 19 Septembre 2018
De 13h30 à 15h
Centre de Recherche - Paris - Amphithéâtre Antoine Lacassagne

Host-parasite coevolutionary arms: Toxoplasma effectors co-opt the host cell (epi)genetic program

The obligate intracellular parasite Toxoplasma gondii strikes a subtle balance with the host immune system that not only prevents host death but also promotes parasite persistence. Although being enclosed within a parasitophorous vacuole (PV), the parasite actively interfaces with host cell signaling pathways, thereby directing host cell responses. The PV membrane has been regarded as a sieve limiting the delivery of proteins secreted by the parasite beyond the vacuolar space. However, the discovery of a large variety of effector proteins originating from dense granule organelles (GRA proteins) and their remarkable ability to cross the PV membrane and to accumulate in the host cell nucleus has changed this paradigm. With this new repertoire of molecular weapons, it can target gene expression at both the transcriptional and posttranscriptional levels by regulating the amount of mRNAs encoding proteins and affecting noncoding RNAs, e.g., microRNAs, respectively. These effectors highlight novel mechanisms by which T. gondii has learned to harness host signaling to favor intracellular survival and will guide future studies designed to uncover the additional complexity of this intricate host-pathogen interaction.

Orateur(s)

Dr Mohamed-Ali HAKIMI
Principal Investigator, Team « Host-Pathogen Interactions & Immunity to Infections », IAB - Institute for Advanced Biosciences INSERM U1209 - CNRS UMR5309 - UGA (University Grenoble Alpes)Grenoble, Rhône-Alpes, France

Organisateur(s)

Dr Fabien Sindikubwabo
Post-Doctorant
Domain 4 - UMR 3666 / U1143 - Chemical Biology of Membranes and Therapeutic Delivery

Institut Curie

Invité(e)(s) par

Dr Fabien Sindikubwabo
Post-Doctorant
Domain 4 - UMR 3666 / U1143 - Chemical Biology of Membranes and Therapeutic Delivery

Institut Curie

Contact

Dr Raphaël Rodriguez

Chef d'équipe: Chimie et Biologie du Cancer UMR3666/U1143

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