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Mercredi 13 Juin 2018
De 11h30 à 12h30
Centre de Recherche - Paris - Amphithéâtre Marie Curie

Chromosome organization and anomalous diffusion in the cell. Theoretical challenges from recent experiments

The chromosome is at the center of a set of interrelated physical and biological processes that are essential for the life of a cell, such as gene transcription and genome replication. In particular, the joint dynamics of the chromosome and its embedding medium contains a wealth of information on its function. However, we still know relatively little about how we should decipher it. Roughly, we should picture it as a complex heterogeneous fluid where the chromosome folded structure, the crowding from surrounding macromolecules, the possible presence of elastic elements and chromosome-associated proteins contribute to the overall (sub)-diffusion of both chromosomal loci and their surrounding medium. In this talk, I will present the main findings emerging from data on short-time mobility in bacteria, and address the current understanding of  two important theoretical challenges that they pose: the nature of the sub-diffusion and the relative roles played by the chromosome and the surrounding medium in causing it.  


Marco Cosentino Lagomarsino
Statistical physics of cells and genomes. IFOM, Milan IT

Computational and Quantitative Biology. CNRS / Sorbonne University, Paris FR

Invité(e)(s) par

Laura Caccianini
Domain 4 - UMR 168 - Physical chemistry

Institut Curie