Chromosome organization and anomalous diffusion in the cell. Theoretical challenges from recent experiments
The chromosome is at the center of a set of interrelated physical and biological processes that are essential for the life of a cell, such as gene transcription and genome replication. In particular, the joint dynamics of the chromosome and its embedding medium contains a wealth of information on its function. However, we still know relatively little about how we should decipher it. Roughly, we should picture it as a complex heterogeneous fluid where the chromosome folded structure, the crowding from surrounding macromolecules, the possible presence of elastic elements and chromosome-associated proteins contribute to the overall (sub)-diffusion of both chromosomal loci and their surrounding medium. In this talk, I will present the main findings emerging from data on short-time mobility in bacteria, and address the current understanding of two important theoretical challenges that they pose: the nature of the sub-diffusion and the relative roles played by the chromosome and the surrounding medium in causing it.
Statistical physics of cells and genomes. IFOM, Milan IT
Computational and Quantitative Biology. CNRS / Sorbonne University, Paris FR
Domain 4 - UMR 168 - Physical chemistry