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Seminar

Tuesday, March 27th, 2018
From 11h30 To 13h
Centre de Recherche - Paris - Amphithéâtre Marie Curie

Dynamics of epithelial cells during collective migration and cell extrusion

The directed migration of cell collectives is essential in various physiological processes, such as epiboly, drosophila dorsal closure and convergent extension during morphogenesis as well as pathological events like wound healing and cancer metastasis. Collective cell migration leads to the emergence of coordinated movements over multiple cells. In the first part, we will show that the establishment of single-cell level polarity could drive coordinated movements of epithelial cells.  We designed a minimalistic model system to generate one-dimensional epithelial trains confined in ring-shaped patterns, permitting simplified biomechanical analysis of collective cell migration. Our approaches show that the maintenance of coordinated migration relies on the acquisition of a front-back polarity of each single cell but not on cell-cell junctions. In the second part, we will show how epithelial movements and stresses drive cell extrusion mechanisms from epithelial tissues.

Speaker(s)

Dr. Benoît LADOUX
Co-Principal Investigator, Mechanobiology Institute, National University of Singapor

Institut Jacques Monod (Université Paris Diderot and CNRS), Mechanobiology Institute (Singapore, NUS)

Invited by

Dr. Philippe Chavrier
Domain 4 - UMR 144 - Subcellular Structure and Cellular Dynamics

Institut Curie

Contact

Dr. Philippe Chavrier

Institut Curie

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