> Back to seminars list

Seminar

Wednesday, March 21st, 2018
From 11h30 To 12h30
Centre de Recherche - Paris - Amphithéâtre Marie Curie

Coarse-grained simulations of biological membranes

Biological membranes have a complex composition with hundreds of different lipids and a high protein concentration. The nature of the lateral structure of membranes is hotly debated as experiments reach increasingly higher spatial and temporal resolution and simulations increasingly larger time and length scales. Coarse-grained simulations with the Martini model have enabled a significant jump in time and length scale for detailed simulations, and currently can reach of the order of 100 microseconds on systems of ca. 100 x 100 nm size on relatively available computers. We are particularly interested the interactions between lipids and membrane proteins. The local environment around membrane proteins is uniquely shaped by the protein surface, resulting in a local composition and membrane properties that differ significantly from the average properties of the lipids that make up the membrane model. This may play an important role in shaping the lateral structure of biological membranes. This type of simulation also enables detailed studies on more specific interactions. I will illustrate this with simulations of lipid interactions with P-glycoprotein, a human ABC transporter involved in multidrug resistance.

Speaker(s)

Prof. Peter Tieleman
Canada Research Chair in Molecular Simulation

Director, Centre for Molecular Simulation

Invited by

Patricia Bassereau
Daniel Lévy