Coordinated regulation of gut microbiome and immune checkpoint activity by the ubiquitin ligase RNF5
The ubiquitin ligase RNF5 has been implicated in the regulation of ER stress, autophagy and glutamine metabolism. Inoculation of melanoma cells in RNF5 KO mice resulted in limited growth, indicating that lack of RNF5 results in effective inhibition of melanoma development. We found that RNF5 limit melanoma growth by coordinating gut microbiome and immune checkpoint activity. How does RNF5 affect the gut microbiome and concomitantly - anti tumor immune response, will be discussed.
Professor and Co-Director, Technion Integrated Cancer Center, Technion, Israel
Domain 1 - UMR 3347 / U1021 - Normal and pathological signaling
Domain 3 - U830 - Genetics and Biology of Cancers