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Seminar

Friday, March 16th, 2018
11h30
Centre de Recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e

Coordinated regulation of gut microbiome and immune checkpoint activity by the ubiquitin ligase RNF5

The ubiquitin ligase RNF5 has been implicated in the regulation of ER stress, autophagy and glutamine metabolism. Inoculation of melanoma cells in RNF5 KO mice resulted in limited growth, indicating that lack of RNF5 results in effective inhibition of melanoma development. We found that RNF5 limit melanoma growth by coordinating gut microbiome and immune checkpoint activity. How does RNF5 affect the gut microbiome and concomitantly - anti tumor immune response, will be discussed. 

Speaker(s)

Ze’ev Ronai, Ph.D.

Professor and Co-Director, Technion Integrated Cancer Center, Technion, Israel

Hosted by

Lionel Larue
Domain 1 - UMR 3347 / U1021 - Normal and pathological signaling

Institut Curie

Mrs. Mechta-Grigoriou Fatima
Domain 3 - U830 - Genetics and Biology of Cancers

Institut Curie

Contact

Lionel Larue

Institut Curie

Send an e-mail

Mrs. Mechta-Grigoriou Fatima

Institut Curie

Send an e-mail