Origin and function of synchronized signaling oscillations during embryonic patterning
Abstract: We study the role of signaling dynamics during embryonic development and hence investigate the function of embryonic clocks, or oscillators. Ultradian oscillations (period ~2 hours) in Wnt, Fgf and Notch signaling pathway activity have been identified in mouse embryos and are linked to periodic mesoderm segmentation and formation of pre-vertebrae, or somites. Most strikingly, Notch signaling oscillations occur highly synchronized between neighbouring cells, leading to the appearance of spatio-temporal wave patterns sweeping through mesodermal cells. Combining real-time imaging of dynamic reporter knock-in mouse lines, functional perturbations and also novel ex-vivo models for mesoderm patterning, I will present our recent results addressing the origin and function of collective signaling oscillations during mesoderm patterning.
Domain 2 - UMR 3215 / U934 - Genetics and Developmental Biology