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Wednesday, May 16th, 2018
Centre de Recherche - Orsay - Amphithéâtre du Bâtiment 111

Diversification of signaling pathways that control embryonic development and cancer

Embryonic signaling pathways underlie key events in early development and often become misregulated in disease.  The Wnt pathway occupies a special place, being involved in cell division, polarization, migration and differentiation.  Besides the beta-catenin pathway that controls cell lineage specification and maintenance, non-canonical Wnt signaling branches regulate cell polarity and behavior.  Using the vertebrate embryo as a model, our studies reveal how the pathway branches in different cellular compartments via positive and negative feedback regulation resulting in signal amplification.  The number of outcomes is amplified by context-dependence, due to cross-talk with other signaling pathways.  Specific mechanisms that generate cell and tissue polarity and trigger epithelial-mesenchymal transition during neural crest development and in metastatic tumors will be discussed.    


Sergei Sokol

Mount Sinai Hospital, New York, USA

Invited by

Beatrice Durand
Domain 1 - UMR 3347 / U1021 - Normal and pathological signaling

Institut Curie


Beatrice Durand

Institut Curie

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