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Séminaire

Vendredi 16 Février 2018
11h
Centre de Recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e

Regulatory T cells, Polymorphisms and Response to Checkpoint blockade: From mechanisms to potential biomarkers

In mice, anti-CTLA-4 monoclonal antibodies (mAbs) require Fc-gamma receptor (FcγR)-mediated depletion of intra-tumoral regulatory T (Treg) cells to promote tumor rejection. However, the relevance of this mechanism in the human setting remains controversial.  Using a mouse model expressing human FcγRs, and analysis of clinical samples from ipilimumab-treated melanoma patients we investigate the potential role of Treg depletion to the activity of antibodies targeting human CTLA-4.

 

Sergio Quezada completed his PhD at Dartmouth, New Hampshire, before working as a postdoc at the Memorial Sloan-Kettering Cancer Center, New York. He then moved to the UK and has been supported by Cancer Research UK from his initial Career Development Fellowship at University College London, to a recently awarded Senior Cancer Research Fellowship.

Orateur(s)

Sergio Quezada
Professorial Research Fellow - Research Department of Haematology

UCL Cancer Institute, London

Invité(e)(s) par

Eliane Piaggio
Domain 3 - U932 - Immunity and Cancer

Institut Curie

Emanuela Romano
Domain 3 - U932 - Immunity and Cancer

Institut Curie

Contact

Sylvia Trival

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