The cancer epigenome: Concepts, challenges, and therapeutic opportunities
Cancer biology is profoundly influenced by changes in the epigenome. Because the dynamic plasticity of the epigenome lends itself well to therapeutic manipulation, the past few years have witnessed an unprecedented investment in the development,characterization, and translation of targeted epigenetic therapies. In this seminar, I will provide a broad context for recent developments that offer a greater understanding of how epigenetic regulators facilitate the initiation, maintenance, and evolution of cancer. I will discuss newly developed epigenetic therapies and the cellular and molecular mechanisms that may govern sensitivity and resistance to these agents. I will also review the rationale for future combination therapies involving existing and emerging epigenetic drugs.
Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre building