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Seminar

Friday, October 13th, 2017
11h
Centre de Recherche - Paris - Amphith√©√Ętre Marie Curie

Environmental sensors of immune regulation at the intestinal barriers

At mucosal tissues, environmental factors often have critical roles regulating immune functions. Commensal bacteria, nutrients and vitamins, as well as food degradation products, all influence how immune cells function. To maintain immunological homeostasis at these mucosal barriers, an exquisite balance coordinating pro-inflammatory and tolerogenic responses is highly required, whereas disruption of this delicate balance might lead to intestinal pathologies, such as food allergies or inflammatory bowel disease (IBD).

The effect of dietary metabolites is mainly mediated by the activity of nuclear receptors, which function as key modulators of gene expression networks that ultimately control the outcome of immune responses. Here I will discuss the immunological influence of some dietary compounds and their metabolites acting through nuclear receptors. In particular, I will discuss the role of Retinoic Acid Receptor (RAR)-a on regulating innate and adaptive immunity. Finally, I will discuss some unpublished data from our own lab showing new models to investigate, in a high throughput fashion, the interaction between pollutants, diet and innate immunity.

Speaker(s)

Eduardo Villablanca
PhD, Assistant Professor

Department of Medicine, Immunology and Allergy Unit, Karolinska Institute (Stockholm, Sweden)

Invited by

Ana-Maria Lennon
Domain 3 - U932 - Immunity and Cancer

Institut Curie

Contact

Ana-Maria Lennon

Institut Curie

Violaine Randrian

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