Environmental sensors of immune regulation at the intestinal barriers
At mucosal tissues, environmental factors often have critical roles regulating immune functions. Commensal bacteria, nutrients and vitamins, as well as food degradation products, all influence how immune cells function. To maintain immunological homeostasis at these mucosal barriers, an exquisite balance coordinating pro-inflammatory and tolerogenic responses is highly required, whereas disruption of this delicate balance might lead to intestinal pathologies, such as food allergies or inflammatory bowel disease (IBD).
The effect of dietary metabolites is mainly mediated by the activity of nuclear receptors, which function as key modulators of gene expression networks that ultimately control the outcome of immune responses. Here I will discuss the immunological influence of some dietary compounds and their metabolites acting through nuclear receptors. In particular, I will discuss the role of Retinoic Acid Receptor (RAR)-a on regulating innate and adaptive immunity. Finally, I will discuss some unpublished data from our own lab showing new models to investigate, in a high throughput fashion, the interaction between pollutants, diet and innate immunity.
PhD, Assistant Professor
Department of Medicine, Immunology and Allergy Unit, Karolinska Institute (Stockholm, Sweden)
Domain 3 - U932 - Immunity and Cancer