Ultraviolet A-induced oxidation in the cornea: short and long-term effects
Human eye is directly exposed to solar ultraviolet (UV) radiations but the retina is protected from those rays. Indeed, the cornea and the lens filter UV rays to protect the retina against their toxicity. The UVA component represents 95% of solar UV radiation and has photo-oxidant properties. However, the consequences of UVA absorption by the cornea are not well understood. Our work focuses on determining the UVA-induced oxidation in cornea and the consequences of this oxidation. We show that the corneal stroma, the structural layer of the cornea, is particularly affected by UVA-induced oxidation and that chronic exposure to UVA causes changes that can be related to photo-aging.
Centre de Recherche du CHU de Québec Université Laval, Québec, Canada
Domain 1 - UMR 3347 / U1021 - Normal and pathological signaling