A liquid crystalline interface between chromosomes controls meiotic recombination
Dr. Dernburg's lab is interested in meiosis, the special division process by which the genetic information on chromosomes is transmitted from parent to progeny through sexual reproduction. Errors in this process lead to aneuploidy and are a major cause of human birth defects such as Down syndrome. They are investigating how chromosomes are reorganized during this unique cell cycle by combining high-resolution imaging of chromosomes in situ and in vivo with the molecular genetic advantages of C. elegans. A fundamental goal of their work is to understand how specific DNA sequences confer not only gene expression patterns but also the large-scale 3-dimensional organization of the genome.
Department of >Molecular & Cell Biology, University of California, Berkeley (CA, USA)
Directeur du Centre de Recherche