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Séminaire

Jeudi 19 Octobre 2017
11h30
Centre de Recherche - Orsay - Amphithéâtre du Bâtiment 111

Structural characterisation of G protein-coupled receptors, What have we learnt?

G Protein Coupled receptors (GPCRs) are integral membrane protein and constitute the largest family of membrane proteins. GPCRs are localised at the plasma membrane of eukaryotic cells. They mediate signal transduction from the extracellular to the intracellular compartment and play an important role in cell communication for physiological and pathological processes. Once activated by their respective ligands, GPCRs undergo conformational changes required for activating intracellular G protein, or arrestin and Kinase recruitment. GPCRs activation can be define by an ensemble of conformational states that are in dynamic equilibrium in the cell. Understanding the molecular basis of ligand binding mode and signal transduction require solving the structure of these different receptor conformation bound to ligand and to intracellular signalling partners. Over the last decade, recent advance in protein engineering and micro crystallography, allowed solving the structure of a large number of GPCRs, representing different conformational states. I will review and illustrate the recent advances in the field by using the human adenosine receptor A2A as a case study. In the second part of my talk, I will show how recent methodology can be apply to other receptors with an example that is currently under investigation in our lab: the human metabotropic glutamate receptor dimer. High-resolution structures of GPCRs provide unprecedented source of information for designing better drugs.

Orateur(s)

Guillaume Lebon

Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier, F-34000 Montpellier (France).

Organisateur(s)

Lionel Larue
Domain 1 - UMR 3347 / U1021 - Normal and pathological signaling

Institut Curie

Véronique Delmas
Domain 1 - UMR 3347 / U1021 - Normal and pathological signaling

Institut Curie

Contact

Lionel Larue

Institut Curie

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