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Lundi 11 Septembre 2017
De 11h30 à 12h30
Centre de Recherche - Paris - Amphithéâtre Marie Curie

Assessing the engines of affinity maturation to vaccines: germinal centers and Tfh cells

T cell help to B cells was one of the earliest discovered functions of T cells, 49 years ago, resulting in the coining of the term ‘helper cell’. Follicular helper T cells (Tfh) are the specialized CD4 T cells for B cell help. Generation of long term humoral immunity is a complex process predominantly dependent on germinal centers and CD4 T cell help to B cells. Germinal centers are the engines of affinity maturation. The vast majority of currently licensed human vaccines work on the basis of long-term protective antibody responses, and thus control of Tfh cells may be a valuable mechanism to immunologically improve the outcomes of immunizations with new candidate vaccines. A greater understanding of how to track, characterize, and induce Tfh cell responses could greatly contribute to the realization of new vaccines. Following up on our recent work on signals and circuits involved in Tfh differentiation, we are exploring a range of approaches to quantify and modify Tfh cell abundance and function in the context of vaccines and infections, including: (1) How can germinal center responses to a vaccine be maximized? (2) What signals can induce human Tfh differentiation? (3) How can antigen-specific GC Tfh cells be tracked and quantified? (4) Can germinal center responses be tracked longitudinally in an animal model? (5) What can we learn about GC Tfh cells in human disease states that can teach us about optimal Tfh help to B cells?


Pr Shane Crotty
PhD, Professor

La Jolla Institute for Allergy & Immunology (LJI), La Jolla, CA, USA

Invité(e)(s) par

Sebastian Amigorena
Domain 3 - U932 - Immunity and Cancer

Institut Curie

Vassili Soumelis
Domain 3 - U932 - Immunity and Cancer

Institut Curie

En savoir plus

Shane Crotty graduated from MIT and then obtained his Ph.D. at the University of California, San Francisco, USA in 2001. He carried out postdoctoral studies at Emory University, USA, with Rafi Ahmed before starting his laboratory at the La Jolla Institute for Allergy & Immunology (LJI), USA, in 2003, where he is now a full Professor. Dr. Crotty’s lab studying the fundamental immunology underlying the functions of vaccines. Initially trained in molecular virology and then viral immunology, Crotty’s laboratory focuses on both the basic immunology of T follicular helper (Tfh) CD4 T cells (Science 2009, Annual Review of Immunology 2011, Immunity 2011, 2013, Nature Immunology 2014, 2015, 2016a, 2016b, 2016c) as well as the central roles of germinal centers and memory in vaccine immunology (Science 2016, Cell Reports 2016, Immunity 2017). Dr. Crotty was named a Pew Scholar in Biomedical Sciences in 2005, and was the 2012 recipient of the American Association of Immunologists (AAI)-BD Biosciences Investigator Award, for outstanding early-career research contributions to the field of Immunology. He was recently named a 2016 Thompson Reuters ISI Highly Cited Researcher, ostensibly a tabulation of the most influential 125 immunologists in the world during the period 2004-2014.