Séminaires Marie Curie

  • Lundi 17 Décembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : David GILBERT (Florida State University)

    Regulation of Replication Timing and Chromosome Architecture

    The temporal order of DNA replication (replication timing, RT) is highly coupled with genome architecture, but cis-elements regulating spatio-temporal control of replication have remained elusive. We performed an extensive series of CRISPR mediated deletions and inversions and high-resolution cap...

  • Lundi 10 Décembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Christiane Nüsslein-Volhard

    Marie Curie Seminar: Christiane Nüsslein-Volhard - How fish colour their skin: A paradigm for development and evolution of adult patterns

    Colour patterns are prominent features of most animals; they are highly variable and evolve rapidly leading to large diversities between species even within a single genus. As targets for natural as well as sexual selection, they are of high evolutionary significance. The zebrafish (Danio rerio) ...

  • Mercredi 7 Novembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Anthony Hyman (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden (Germany))

    The role of phase separation in organising cellular biochemistry

    We are actively studying the physical mechanisms of phase separation in the lab, using biophysical, genetic, and chemical methods. The principles of phase separation also inform our understanding of the formation of centrosomes, another active area of research in the lab. Click the buttons below ...

  • Jeudi 11 Octobre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Claudio Stern (Department of Cell & Developmental Biology, University College of London (UK))

    Gastrulation through a primitive streak : cellular mechanisms & signals

    Amniote (birds and most mammals) embryos have the remarkable ability to undergo “embryonic regulation”: this is a property by which a fragment of the embryo can reconstitute the entire embryo. This can occur right up to the appearance of the primitive streak (14th day in humans), and ...

  • Mardi 25 Septembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Alfonso VALENCIA (BSC Barcelona Supercomputing Center)

    Networks based approaches in epigenomics, evolution and biomedicine

    Network biology, a growing field of Computational Biology, opens great new possibilities for the study of complex biological systems. In this presentation, I will review four specific cases of the application network approaches. In the first study, we processed heterogeneous ChIP-Seq informati...

  • Mardi 18 Septembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Stephen J. Simpson (Charles Perkins Centre, The University of Sydney)

    Models and model systems: the nutritional geometry of health and ageing

    The question of what represents a balanced diet and how this maintains health and longevity remains unanswered. The talk will set out an integrative framework, Nutritional Geometry, for describing the multidimensional nature of nutritional requirements, the relative values of foods in relation to...

  • Lundi 28 Mai 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Thanos Halazonetis (Department of Molecular Biology, University of Geneva, Switzerland)

    DNA replication stress and cancer

    Genomic instability is one of the most important factors driving cancer progression and resistance to therapy. Oncogenes, by inducing DNA replication stress, are a critical factor underlying genomic instability in cancer, but the mechanisms by which oncogenes cause DNA replication stress have rem...

  • Mercredi 7 Février 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Phillip Zamore (RNA Therapeutics Institute, University of Massachusetts Medical School, and  Howard Hughes Medical Institute)

    What flies can and can’t teach us about piRNAs

    In animals, PIWI-interacting RNAs (piRNAs) serve as guides for the PIWI clade of Argonaute proteins, an evolutionary conserved family of RNA-binding proteins at the heart of eukaryotic gene silencing pathways. Flies teach us that piRNAs protect the germline from transposons and repetitive sequenc...

  • Jeudi 21 Décembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Brent Stockwell (Departments of Biological Sciences and Chemistry, Columbia University)

    Ferroptosis: a regulated cell death nexus linking metabolism, redox biology and disease

    Abstract: Dr. Stockwell will describe the discovery of ferroptosis, a form of regulated cell death characterized by the iron-dependent accumulation of lethal lipid hydroperoxides.  Current data suggest that ferroptosis is an ancient vulnerability caused by the evolution of cells with polyunsatura...

  • Vendredi 24 Novembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Robert A. Martienssen (Cold Spring Harbor Laboratory, New York - USA)

    Small interfering RNA in replication, recombination and repair

    Rob Martienssen is investigating the role of heterochromatin reprogramming and RNA interference in plant germ cells. These mechanisms reveal and regulate transposable elements, but they also play important roles in meiosis and reproductive fate.

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