Marie Curie Seminars
 Monday, 15th, April 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Adrian Krainer (Cold Spring Harbor Laboratory, Long Island, NY, USA) Targeted Antisense Therapeutics for Modulation of Splicing or NMDPr. Adrian KRAINER has made huge contributions to our understanding of splicing factors and their role in regulating alternative splicing. In a culmination of this success, he has identified ways to control alternative splicing patterns ... |
 Wednesday, 13th, March 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : John Marko (Department of Molecular Biosciences, Northwestern University, Evanston, USA) Mechanics, topology and geometry of mammalian chromosomes and nuclei and their modulation by histone epigenetic marksOur lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models ... |
 Friday, 15th, February 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Eric Miska (Gurdon Institute, Univeristy of Cambridge, Cambridge, UK) An ancient machinery drives piRNA transcription in C. elegansPiwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and nonself nucleic acids and maintain genome integrity and are essential for fertility in a variety of organisms. In Caenorhabditis elegans, most piRNA precursors are transcribed from two genomic clusters that contain th... |
Integration of Glycomics, Development, and ImmunologyLudger Johannes has invited Pr Richard D. Cummings from Beth Israel Deaconess Medical Center Harvard Medical School to come and give a talk on "Integration of Glycomics, Development, and Immunology". He will also participate in the Pastor's course |
 Friday, 18th, January 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : George Demetri (Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston USA) Precise and imprecise therapeutic targeting of sarcomas across the age spectrumThe biological and clinical diversity of sarcomas represents both a scientific opportunity and a medical challenge. Although cytotoxic chemotherapy can be curative for an important subset of patients, advances in technology have allowed us to identify mechanisms of oncogenic drivers and therapeu... |
 Friday, 18th, January 2019 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Véronique Gouverneur (University of Oxford, UK ) Late stage (radio)fluorination. Lessons to be learned from the fluorinase enzymeThe impact of fluorine chemistry in the life sciences is enormous. As many as 30−40% of agrochemicals and 20% of pharmaceuticals on the market are estimated to contain fluorine. 19F- and 18F-labelled compounds are also finding increasing applications in imaging such as Magnetic Resonance I... |
 Monday, 17th, December 2018 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : David GILBERT (Florida State University) Regulation of Replication Timing and Chromosome ArchitectureThe temporal order of DNA replication (replication timing, RT) is highly coupled with genome architecture, but cis-elements regulating spatio-temporal control of replication have remained elusive. We performed an extensive series of CRISPR mediated deletions and inversions and high-resolution cap... |
Marie Curie Seminar: Christiane Nüsslein-Volhard - How fish colour their skin: A paradigm for development and evolution of adult patternsColour patterns are prominent features of most animals; they are highly variable and evolve rapidly leading to large diversities between species even within a single genus. As targets for natural as well as sexual selection, they are of high evolutionary significance. The zebrafish (Danio rerio) ... |
 Wednesday, 7th, November 2018 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Anthony Hyman (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden (Germany)) The role of phase separation in organising cellular biochemistryWe are actively studying the physical mechanisms of phase separation in the lab, using biophysical, genetic, and chemical methods. The principles of phase separation also inform our understanding of the formation of centrosomes, another active area of research in the lab. Click the buttons below ... |
 Thursday, 11th, October 2018 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Claudio Stern (Department of Cell & Developmental Biology, University College of London (UK)) Gastrulation through a primitive streak : cellular mechanisms & signalsAmniote (birds and most mammals) embryos have the remarkable ability to undergo “embryonic regulation”: this is a property by which a fragment of the embryo can reconstitute the entire embryo. This can occur right up to the appearance of the primitive streak (14th day in humans), and ... |
Networks based approaches in epigenomics, evolution and biomedicineNetwork biology, a growing field of Computational Biology, opens great new possibilities for the study of complex biological systems. In this presentation, I will review four specific cases of the application network approaches. In the first study, we processed heterogeneous ChIP-Seq informati... |
 Tuesday, 18th, September 2018 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Stephen J. Simpson (Charles Perkins Centre, The University of Sydney) Models and model systems: the nutritional geometry of health and ageingThe question of what represents a balanced diet and how this maintains health and longevity remains unanswered. The talk will set out an integrative framework, Nutritional Geometry, for describing the multidimensional nature of nutritional requirements, the relative values of foods in relation to... |
DNA replication stress and cancerGenomic instability is one of the most important factors driving cancer progression and resistance to therapy. Oncogenes, by inducing DNA replication stress, are a critical factor underlying genomic instability in cancer, but the mechanisms by which oncogenes cause DNA replication stress have rem... |
 Wednesday, 7th, February 2018 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Phillip Zamore (RNA Therapeutics Institute, University of Massachusetts Medical School, and Howard Hughes Medical Institute) What flies can and cant teach us about piRNAsIn animals, PIWI-interacting RNAs (piRNAs) serve as guides for the PIWI clade of Argonaute proteins, an evolutionary conserved family of RNA-binding proteins at the heart of eukaryotic gene silencing pathways. Flies teach us that piRNAs protect the germline from transposons and repetitive sequenc... |
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology and diseaseAbstract: Dr. Stockwell will describe the discovery of ferroptosis, a form of regulated cell death characterized by the iron-dependent accumulation of lethal lipid hydroperoxides. Current data suggest that ferroptosis is an ancient vulnerability caused by the evolution of cells with polyunsatura... |
 Friday, 24th, November 2017 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Robert A. Martienssen (Cold Spring Harbor Laboratory, New York - USA) Small interfering RNA in replication, recombination and repairRob Martienssen is investigating the role of heterochromatin reprogramming and RNA interference in plant germ cells. These mechanisms reveal and regulate transposable elements, but they also play important roles in meiosis and reproductive fate. |
 Monday, 9th, October 2017 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Jürgen Knoblich (Institute of Molecular Biotechnology (IMBA), Vienna, Austria) Neural stem cells and brain development: From Drosophila to humansThe human brain is the most fascinating and most complex organ of all. Despite this enormous complexity, the billions of neurons in our brain arise from a limited number of progenitors following a specific set of lineage decisions. We combine Drosophila genetics with 3D organoid cultures derived ... |
 Wednesday, 27th, September 2017 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Hans Clevers (Hubrecht Institute, Utrecht, the Netherlands) Stem cell-grown organoids as models for human diseaseThe intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally defined Lgr5 as a Wnt target gene, transcribed in colon cancer cells. Two knock-in alleles revealed exclusive expression of Lgr5 in cycling, columnar cells at the crypt base. Using lineage tracing e... |
 Thursday, 22nd, June 2017 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Carlos Caldas (Cancer Research UK Cambridge Institute, Cambridge, UK) Breast cancers are communities of clones and communities of cellsProfessor Caldas holds the Chair of Cancer Medicine at the University of Cambridge since 2002. He heads the Breast Cancer Functional Genomics Laboratory at the Cancer Research UK Cambridge Research Institute. He is an Honorary Consultant Medical Oncologist at Addenbrooke's Hospital, and Director ... |
 From Monday, 15th, May 2017 To Tuesday, 16th, May 2017 - Séminaire institutionnel "Marie Curie Seminar" Speaker(s) : Douglas Green (St. Jude Children's Research Hospital, Memphis, USA) To the edge of necroptosis and backPublications: Gong, Y., Guy, C. Olauson, H., Becker, J.U., Yang, M., Fitzgerald, P., Linkermann, A., and Green, D.R. ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences. Cell, in press. Quarato, G., Guy, C.S., Grace, C.R., Llambi, F., Nourse, A., Rodr... |