Séminaires Marie Curie
 Lundi 17 Décembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : David GILBERT (Florida State University) Regulation of Replication Timing and Chromosome ArchitectureThe temporal order of DNA replication (replication timing, RT) is highly coupled with genome architecture, but cis-elements regulating spatio-temporal control of replication have remained elusive. We performed an extensive series of CRISPR mediated deletions and inversions and high-resolution cap... |
Marie Curie Seminar: Christiane Nüsslein-Volhard - How fish colour their skin: A paradigm for development and evolution of adult patternsColour patterns are prominent features of most animals; they are highly variable and evolve rapidly leading to large diversities between species even within a single genus. As targets for natural as well as sexual selection, they are of high evolutionary significance. The zebrafish (Danio rerio) ... |
 Mercredi 7 Novembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Anthony Hyman (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden (Germany)) The role of phase separation in organising cellular biochemistryWe are actively studying the physical mechanisms of phase separation in the lab, using biophysical, genetic, and chemical methods. The principles of phase separation also inform our understanding of the formation of centrosomes, another active area of research in the lab. Click the buttons below ... |
 Jeudi 11 Octobre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Claudio Stern (Department of Cell & Developmental Biology, University College of London (UK)) Gastrulation through a primitive streak : cellular mechanisms & signalsAmniote (birds and most mammals) embryos have the remarkable ability to undergo “embryonic regulation”: this is a property by which a fragment of the embryo can reconstitute the entire embryo. This can occur right up to the appearance of the primitive streak (14th day in humans), and ... |
Networks based approaches in epigenomics, evolution and biomedicineNetwork biology, a growing field of Computational Biology, opens great new possibilities for the study of complex biological systems. In this presentation, I will review four specific cases of the application network approaches. In the first study, we processed heterogeneous ChIP-Seq informati... |
 Mardi 18 Septembre 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Stephen J. Simpson (Charles Perkins Centre, The University of Sydney) Models and model systems: the nutritional geometry of health and ageingThe question of what represents a balanced diet and how this maintains health and longevity remains unanswered. The talk will set out an integrative framework, Nutritional Geometry, for describing the multidimensional nature of nutritional requirements, the relative values of foods in relation to... |
DNA replication stress and cancerGenomic instability is one of the most important factors driving cancer progression and resistance to therapy. Oncogenes, by inducing DNA replication stress, are a critical factor underlying genomic instability in cancer, but the mechanisms by which oncogenes cause DNA replication stress have rem... |
 Mercredi 7 Février 2018 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Phillip Zamore (RNA Therapeutics Institute, University of Massachusetts Medical School, and Howard Hughes Medical Institute) What flies can and cant teach us about piRNAsIn animals, PIWI-interacting RNAs (piRNAs) serve as guides for the PIWI clade of Argonaute proteins, an evolutionary conserved family of RNA-binding proteins at the heart of eukaryotic gene silencing pathways. Flies teach us that piRNAs protect the germline from transposons and repetitive sequenc... |
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology and diseaseAbstract: Dr. Stockwell will describe the discovery of ferroptosis, a form of regulated cell death characterized by the iron-dependent accumulation of lethal lipid hydroperoxides. Current data suggest that ferroptosis is an ancient vulnerability caused by the evolution of cells with polyunsatura... |
 Vendredi 24 Novembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Robert A. Martienssen (Cold Spring Harbor Laboratory, New York - USA) Small interfering RNA in replication, recombination and repairRob Martienssen is investigating the role of heterochromatin reprogramming and RNA interference in plant germ cells. These mechanisms reveal and regulate transposable elements, but they also play important roles in meiosis and reproductive fate. |
 Lundi 9 Octobre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Jürgen Knoblich (Institute of Molecular Biotechnology (IMBA), Vienna, Austria) Neural stem cells and brain development: From Drosophila to humansThe human brain is the most fascinating and most complex organ of all. Despite this enormous complexity, the billions of neurons in our brain arise from a limited number of progenitors following a specific set of lineage decisions. We combine Drosophila genetics with 3D organoid cultures derived ... |
 Mercredi 27 Septembre 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Hans Clevers (Hubrecht Institute, Utrecht, the Netherlands) Stem cell-grown organoids as models for human diseaseThe intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally defined Lgr5 as a Wnt target gene, transcribed in colon cancer cells. Two knock-in alleles revealed exclusive expression of Lgr5 in cycling, columnar cells at the crypt base. Using lineage tracing e... |
 Jeudi 22 Juin 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Carlos Caldas (Cancer Research UK Cambridge Institute, Cambridge, UK) Breast cancers are communities of clones and communities of cellsProfessor Caldas holds the Chair of Cancer Medicine at the University of Cambridge since 2002. He heads the Breast Cancer Functional Genomics Laboratory at the Cancer Research UK Cambridge Research Institute. He is an Honorary Consultant Medical Oncologist at Addenbrooke's Hospital, and Director ... |
 Du Lundi 15 Mai 2017 Au Mardi 16 Mai 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Douglas Green (St. Jude Children's Research Hospital, Memphis, USA) To the edge of necroptosis and backPublications: Gong, Y., Guy, C. Olauson, H., Becker, J.U., Yang, M., Fitzgerald, P., Linkermann, A., and Green, D.R. ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences. Cell, in press. Quarato, G., Guy, C.S., Grace, C.R., Llambi, F., Nourse, A., Rodr... |
Integration of actin dynamics and adhesion in cell migrationClare Waterman graduated from the Mount Holyoke college with a B.A. in biochemistry in 1989, received an M.S. in exercise science in 1991 from the University of Massachusetts, and received her Ph.D. in cell biology from the University of Pennsylvania in 1995. Prior to joining the NHLBI, she spent... |
 Lundi 27 Mars 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Samie R. Jaffrey (Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA) The dynamic epitranscriptome: Encoding the fate and function of mRNA with reversible nucleotide modificationsAn emerging concept in gene expression regulation is that a diverse set of modified nucleotides is found internally within mRNA, and these modifications constitute an epitranscriptomic code. Our transcriptome-wide map of N6-methyladenosine (m6A) provided the initial understanding of the pervasiv... |
 Vendredi 10 Mars 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Harmit Malik (Fred Hutchinson Research Center, USA) Epigenetics evolution related to chromatinHarmit Malik got his degree in Chemical Engineering from the Indian Institute of Technology in Mumbai graduated as MSc in Chemical Engineering from the Technical University. He was then awarded a PhD in Biology from the University of Rochester for his research on the evolutionary origins of retro... |
 Vendredi 24 Février 2017 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Greg Hannon (Cancer Research UK Cambridge Institute) A small RNA-based innate immune system guards the integrity of germ cell genomesPIWI-family proteins and their associated small RNAs (piRNAs) act in an evolutionarily conserved innate immune mechanism that provides an essential protection for germ cell genomes against the activity of mobile genetic elements. piRNA populations comprise a molecular definition of transposons th... |
 Lundi 10 Octobre 2016 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Peter Lawrence (Cambridge University, UK) Lessons from a lifetime researching developmental biologyPeter Lawrence, Cambridge University, UK This seminar is a part of the 7th course on "DEVELOPMENTAL BIOLOGY COURSE: From Stem Cells to Morphogenesis" (October 10-21, 2016) which takes place at Institut Curie - Paris, Amphitheater BDD. More information here. Organizers: A. Bardin, Y. Bellaïc... |
 Lundi 25 Avril 2016 - Séminaire institutionnel "Marie Curie Seminar" Orateur(s) : Thomas Cech (BioFrontiers Institute, Boulder USA) How Mutations Activate a Telomerase Gene and Help Drive CancerHow Mutations Activate a Telomerase Gene and Help Drive Cancer |