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  • Mardi 13 Novembre 2018 - Séminaire Cell Biology Series Orateur(s) : Lukas HUBER, PhD

    LAMTOR and BORC regulate the position and size of late endosomes/lysosomes

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  • Mardi 13 Novembre 2018 - Séminaire Orateur(s) : VectorBuilder

    A revolutionary platform for vector design, custom cloning and virus packaging

    VectorBuilder is a revolutionary online platform aimed at providing researchers with one-stop solutions to all their vector design, custom cloning and virus packaging needs. Besides cloning and virus packaging, VectorBuilder offers many other molecular biology services such as BAC modification (r...

  • Mercredi 14 Novembre 2018 - Séminaire Orateur(s) : Eric Schirmer (The Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, and Centre for Translational and Chemical Biology - University of Edinburgh,)

    Nuclear envelope mechanics and genome tethering in gene regulation: constrained diffusion and the lamin spring

    The nuclear envelope (NE) is a complex double membrane system supported by the intermediate filament lamin polymer and many NE transmembrane proteins (NETs) that connect it to both cytoplasmic filaments from the outer nuclear membrane and chromatin from the inner nuclear membrane. These latter co...

  • Mercredi 14 Novembre 2018 - Séminaire Orateur(s) : Eric Schirmer (The Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, and Centre for Translational and Chemical Biology - University of Edinburgh,)

    Nuclear envelope mechanics and genome tethering in gene regulation: constrained diffusion and the lamin spring

    The nuclear envelope (NE) is a complex double membrane system supported by the intermediate filament lamin polymer and many NE transmembrane proteins (NETs) that connect it to both cytoplasmic filaments from the outer nuclear membrane and chromatin from the inner nuclear membrane. These latter co...

  • Mercredi 14 Novembre 2018 - Séminaire Orateur(s) : VectorBuilder

    A revolutionary platform for vector design, custom cloning and virus packaging

    VectorBuilder is a revolutionary online platform aimed at providing researchers with one-stop solutions to all their vector design, custom cloning and virus packaging needs. Besides cloning and virus packaging, VectorBuilder offers many other molecular biology services such as BAC modification (r...

  • Mercredi 14 Novembre 2018 - Séminaire Orateur(s) : Marcus Braun (Institute of Biotechnology Czech Academy of Sciences, Prague, Czech Republic)

    Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

    Tau is an intrinsically disordered protein, which diffuses on microtubules. In neurodegenerative diseases collectively termed tauopathies, tau malfunction and its detachment from axonal microtubules is correlated with microtubule degradation. It is known that tau can protect microtubules from mic...

  • Vendredi 16 Novembre 2018 - Séminaire Orateur(s) : Christoph Thiele (Rheinische Friedrich-Wilhelms-Universität, Bonn, Allemagne)

    Multiplexed mass spectrometric lipid metabolic tracing with single cell sensitivity

    Lipid metabolic tracing is a key technology to understand lipid metabolism in health and disease. We have previously demonstrated tracing with picomole sensitivity and lipid class resolution using alkyne-labeled lipids and detection by fluorogenic click reaction combined with TLC separation. To t...

  • Lundi 19 Novembre 2018 - Séminaire Orateur(s) : Martine Roussel (St. Jude Children's Research Hospital, Memphis, USA)

    Pediatric medulloblastoma: Molecular Pathways and Pre-Clinical Trials

    Medulloblastoma (MB) is the most common malignant brain tumor that develops in the cerebellum. MB occurs mostly in children between the ages of 3-7 years. Human MBs are classified into four major subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3) and G4, each of which has distinct mole...

  • Mardi 20 Novembre 2018 - Séminaire Cell Biology Series Orateur(s) : Ruth KROSCHEWSKI (ETH Zurich - Institute of Biochemistry, Zurich)

    Plasmid DNA transfection, revealing tolerant yet separatist mammalian cells

    The genome of mammalian cells is challenged by extra-chromosomal DNA introduced by viruses, bacteria, or transfection of plasmid DNA. However, how cells handle these DNA molecules is largely unknown. We analyzed predominantly Hela cells stably expressing fluorescently tagged LacI protein and t...

  • Mercredi 21 Novembre 2018 - Séminaire Orateur(s) : David Lacoste (Laboratoire PCT, ESPCI)

    From transient compartmentalization to cell population dynamics

    In the fifties, Oparin imagined liquidlike compartments called  coacervates, which could have played a central role in the origin of life [1]. Although the experimental verification of this idea remained scarce for many years, the idea resurfaced recently in various systems of biological...

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