Liste des séminaires
 Mercredi 17 Avril 2024 - Séminaire Orateur(s) : Sophie Marbach The Countoscope: Measuring Dynamics by Counting Particles in BoxesAny imaging technique is limited by lts field of view. As objects or particles move in and out of the observation field, tracking their motion, especially over long periods, beoomes challenging. ln addition, available analysis techniques face challenges reconstructing trajectories in dense and he... |
 Mercredi 24 Avril 2024 - Séminaire Orateur(s) : Kristina Ganzinger High-speed imaging of droplet and vesicle formation during emulsion transfer (cDICE)Giant unilamellar vesicles (GUVs) are widely used as in vitro model membranes in biophysics and as cell-sized containers in synthetic biology. Despite their ubiquitous use, there is no one-size-fits-all method for their production. Numerous methods have been developed to meet the demanding requir... |
Mechanics of Neural Crest Development: From Induction to Migration and DifferentiationThe neural crest is an embryonic cell population whose migratory behavior has been likened to cancer invasion during metastasis. Neural crests differentiate into a wide array of cell types, including muscle, cartilage, bones, melanocytes, neurons, and glia. Although the role of mechanical cues ha... |
On the multiple roads to cell fate decisions: Integrating transcription factors into RNA-regulatory networksWhile the current view states that Transcription Factors (TFs) act on DNA regulatory elements to deploy precise gene programs, an emerging concept proposes that TFs also bind RNA and regulate splicing to promote molecular and cellular diversity. Yet, how the RNA regulatory functions of TFs contri... |
 Vendredi 3 Mai 2024 - Séminaire Orateur(s) : Anne Brunet (Stanford University School of Medicine) Understanding and modeling agingAging is associated with a decline in tissue function and the onset of a constellation of diseases. We are interested in understanding aging, with a particular focus on brain aging. Because aging is complex, we use organisms with diverse lifespans – the worm C. elegans, the African killifis... |
 Lundi 13 Mai 2024 - Séminaire Orateur(s) : Jeroen Roose (University of California, San Francisco) Deconstruct-Reconstruct Decode cancer-immune crosstalk & probe with organoids.The Roose team at UCSF studies mechanisms of cell-cell interactions in immunology and cancer1-7, with emphasis on personalized medicine4,8 and single cell approaches9-11. Over the past 7 years, we shifted a large portion of our research efforts to understanding human biology and disease. We are d... |
 Mardi 21 Mai 2024 - Séminaire Orateur(s) : Hironori Funabiki (The Rockefeller University, New York) Nucleosomes and DNA methylation implications for immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome and cancersDNA methylation is a broadly observed epigenetic modification. As genomic DNA methylation profiles dynamically change during development and aging, alterations in DNA methylation patterns are linked to diseases such as cancers and immunodeficiency. ICF syndrome is characterized by hypomethylation... |
 Vendredi 31 Mai 2024 - Séminaire Orateur(s) : Wei Yang (National Institute of Health - NIH) Cutting and Pasting DNA to Create our Adaptive Immune SystemV(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/... |
Endocytic control of cell plasticity in cancerOver the past two decades, there has been a significant shift in our understanding of the role of endocytosis and trafficking of signaling receptors. It has evolved from being viewed simply as a signal extinguisher (resulting in long-term attenuation) to being recognized as a sophisticated mechan... |