In-cell NMR spectroscopy: Monitoring of structure, stability, and interactions of DNA at high resolution in nuclei of living human cells.

The structure, dynamics and interactions of nucleic acids, DNA in particular, sensitively respond to a broad range of environmental factors many of them being natively present in intracellular space.  In-cell NMR spectroscopy is a tailored adaptation of conventional high-resolution nuclear magnet...

Understanding Leukemia through the Lens of Normal Development: Single-cell studies for Clinical Translation

Acute leukemia is the most common cancer of childhood and one of the most deadly due to relapsed disease. Predicting patients at high risk of relapse is an imperfect science and currently combines clinical features, somatic alterations and early response to therapy. Yet, despite this, for the 20%...

Spatio-temporal dynamics of damage response proteins: the impact of lesion and chromatin complexity