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  • Mardi 24 Novembre 2020 - Séminaire Nuclear dynamic series Orateur(s) : Christian Lesterlin (Institut de Biologie et Chimie des Protéines)

    Real-time visualization of drug resistance acquisition by horizontal gene transfer reveals a new role for AcrAB-TolC multidrug efflux pump

    Drug resistance dissemination by horizontal gene transfer remains poorly understood at the cellular scale. Using live-cell microscopy, we reveal the dynamics of resistance acquisition by transfer of the F conjugative plasmid encoding the tetracycline-efflux pump TetA. We show that the entry of th...

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